RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-10a
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
GO; pathway enrichment analyses; dual-luciferase reporter assay
Target
BCL6
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
Modulation of miR-10a-mediated TGF-beta1/Smads signaling affects atrial fibrillation-induced cardiac fibrosis and cardiac fibroblast proliferation.
Year
2019
Function
"Down-regulation of miR-10a may inhibit collagen formation, reduce atrial structure remodeling, and decrease proliferation of cardiac fibroblasts (CFs), eventually suppressing cardiac fibrosis in af rats via inhibition of the TGF-beta1/smads signaling pathway."